The biomolecular and ultrastructural basis of epidermolysis bullosa.

نویسندگان

  • C Solovan
  • M Ciolan
  • L Olariu
چکیده

Transmission electron microscopy, immunoelectron microscopy, immunofluorescence and antigenic mapping have improved our understanding of the dermo-epidermal junction. We have reviewed some ultrastructural and biomolecular aspects related to the dermo-epidermal junction. In part, they are implicated in the pathogenesis of a group of hereditary disorders characterized by skin fragility, collectively known as epidermolysis bullosa (EB). These disorders could benefit in the near future from a gene therapy approach but at present genetic counseling, prenatal diagnosis and conservative treatment measures offer little real benefit to patients.

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عنوان ژورنال:
  • Acta dermatovenerologica Alpina, Pannonica, et Adriatica

دوره 14 4  شماره 

صفحات  -

تاریخ انتشار 2005